Migraine attack Recommended dose: 2.5 mg. Take a 2nd dose if symptoms persist or return w/in 24-hr but not w/in 2-hr of initial dose. Subsequent attacks can be treated w/ 5 mg if satisfactory relief is not achieved w/ 2.5 mg dose. Recurrent attacks Max dose: 10 mg in 24-hr period. Moderate or severe hepatic impairment Max dose: 5 mg in 24-hr period.
Hypersensitivity. Uncontrolled HTN. Ischaemic heart disease. Coronary vasospasm/Prinzmetal's angina. CVA or transient ischaemic attack history. Concomitant administration w/ ergotamine or its derivatives or other 5-HT1 receptor agonists.
Possible anaphylaxis/anaphylactoid reactions. Exclude other potentially serious neurological conditions. Hemiplegic or basilar migraine. Risk of cerebral & subarachnoid haemorrhage, stroke & other cerebrovascular events; associated w/ coronary vasospasm, angina pectoris & MI; atypical sensations over the precordium; transient increases in systemic BP in patients w/ or w/o history of HTN. Not to be given to patients w/ symptomatic Wolff-Parkinson-White syndrome or arrhythmias associated w/ other cardiac accessory conduction pathways. Do not take further doses if chest pain or symptoms consistent w/ ischaemic heart disease occur. Patients w/ phenylketonuria; contains phenylalanine. Combined use of triptans & serotonergic drugs (eg, SSRIs & SNRIs) may cause serotonin syndrome. Carefully observe patient during treatment initiation & dosage increases when used concomitantly w/ SSRI or SNRI. Potential treatment w/drawal due to increased headache frequency w/ excessive use. Prolonged use of any type of painkiller for headaches. Somnolence may occur. Not indicated for prophylaxis of migraine. Pregnancy & lactation. Not recommended in childn <12 yr & adolescents 12-17 yr. Elderly >65 yr.
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